Oral Contraceptives Use and Liver Cancer Risk
نویسنده
چکیده
Studies about the association between oral contraceptives use and liver cancer risk have generated controversial results. Therefore, a meta-analysis of cohort and case-control studies was performed to quantitatively summarize the existing evidence.Eligible studies were identified by a computer search of PubMed and Embase databases and handed-search of reference lists, without any limitations. Study-specific risk estimates (RRs) with 95% confidence intervals (CIs) were combined with random-effects model.A total of 17 articles were included in this meta-analysis. Overall, there was no statistically significant association between oral contraceptives use and liver cancer risk (RR: 1.23, 95% CI: 0.93-1.63). In a dose-analysis of meta-analysis, a linear relationship between oral contraceptives use and liver cancer risk (P for linearity = 0.391) was found, although this correlation was not statistically significant.Oral contraceptives use was not positively associated with the risk of liver cancer.
منابع مشابه
Oral Contraceptives and Cancer Risk - National Cancer Institute
Key Points A number of studies suggest that current use of oral contraceptives (birth control pills) appears to slightly increase the risk of breast cancer, especially among younger women. However, the risk level goes back to normal 10 years or more after discontinuing oral contraceptive use. Women who use oral contraceptives have reduced risks of ovarian and endometrial cancer. This protective...
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Some cancers depend on naturally occurring sex hormones for their development and growth. Researchers are interested in learning whether the hormones in oral contraceptives affect cancer risk in women (see Question 1). Some studies have shown an increased risk of breast cancer in women taking oral contraceptives, while other studies have shown no change in risk (see Question 2). Oral cont...
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The epidemiological and clinical evidence for various forms of exogenous estrogens altering the risk of neoplasms of the female genital system, breast, and liver are reviewed and evaluated. It is virtually certain that in utero exposure to diethylstilbestrol can cause clear cell adenocarcinomas of the vagina and cervix. There is strong evidence that various estrogens given for treatment of meno...
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